TLR4 single nucleotide polymorphisms and thrombosis risk in patients with myeloproliferative disorders.
نویسندگان
چکیده
a Department of Immunology and Histocompatibility, School of Medicine, University Hospital of Thessaly, Larissa, 41110 Larissa, Greece b Hematology Department, Papageorgiou Hospital, Thessaloniki, Greece c Theagenion Anticancer Hospital, Thessaloniki, Greece d Department of Internal Medicine, Aristotle University of Thessaloniki, Greece e Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece f Department of Biomathematics, University of Thessaly, School of Medicine, Larissa, Greece
منابع مشابه
بررسی ارتباط پلی‌مورفیسم Thr399Ile از ژن TLR4 در بیماران مبتلا به دیابت نوع دو مراجعه کننده به کلینیک تخصصی وفوق تخصصی دیابت وبیماری‌های متابولیک تهران
Background: Type 2 diabetes is a metabolic disorder characterized by high blood sugar levels that can damage nerves. Many organs are affected ،especially the foot that leading to loss of sensation. These factors make favorable conditions for the development of diabetic foot ulcers. Polymorphisms (Thr399Ile) of Toll Like Receptor4 (TLR4) gene due to malfunction of TLR4 protein which plays an imp...
متن کاملP-246: Gene Variation of TLR4 in Patients with Endometriosis
Background: Endometriosis, defined as the presence of endometrial tissue outside of the uterus, is an estrogen-dependent chronic inflammatory condition associated with degrees of pelvic pain and infertility. Toll-like receptors play a key role in immune response, by regulating inflammatory reactions and activating adaptive immune response to eliminate infectious pathogens and cancer debris. Pol...
متن کاملAssociation of two single nucleotide polymorphisms rs10407022 and rs3741664 with the risk of primary ovarian insufficiency in a sample of Iraqi women
Primary ovarian insufficiency (POI) can be a devastating disease impacting women below the age of forty. This involves a major decrease in the amount and quality of oocytes, or ovarian reserve in a woman. The distribution of single-nucleotide polymorphisms, rs10407022 and rs3741664, in Iraqi people and its association with primary ovarian insufficiency is the main objective of this study. The m...
متن کاملThe predictive role of toll-like receptor-4 genetic polymorphisms in susceptibility to and prognosis of prostatic hyperplasia
Objective(s): This study was aimed to evaluate whether single nucleotide polymorphisms (SNPs) of TLR4 and common living habits of prostate hyperplasia (BPH) patients would affect the subjects’ risk and prognosis.Materials and Methods: We totally recruited 501 BPH patients and 964 healthy controls. The patients’ international prostate symptom score (IPSS) and quality of life assessment (QoL) wer...
متن کامل5-Fluorouracil Induce the Expression of TLR4 on HCT116 Colorectal Cancer Cell Line Expressing Different Variants of TLR4
Two common single nucleotide polymorphisms (SNPs) of the human TLR4 gene, namely Asp299Gly (D299G) and Thr399Ile (T399I), have been shown to impair the ability of certain individuals to respond properly to TLR4 ligands. 5-Fluorouracil (5-FU) is widely used for the treatment of patients with advanced colon cancers. The present study examined the impact of two common polymorphisms of the TLR4 gen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Thrombosis research
دوره 122 1 شماره
صفحات -
تاریخ انتشار 2008